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In chemical terms, adrenaline is one of a group of monoamines called the catecholamines. Adrenaline is synthesized in the chromaffin cells of the adrenal medulla of the adrenal gland and a small number of neurons in the medulla oblongata in the brain through a metabolic pathway that converts the amino acids phenylalanine and tyrosine into a series of metabolic intermediates and, ultimately, adrenaline.

Then it is subsequently decarboxylated to give dopamine by DOPA decarboxylase aromatic L-amino acid decarboxylase.

Dopamine is then converted to noradrenaline by dopamine beta-hydroxylase which utilizes ascorbic acid Vitamin C and copper.

The final step in adrenaline biosynthesis is the methylation of the primary amine of noradrenaline. This reaction is catalyzed by the enzyme phenylethanolamine N -methyltransferase PNMT which utilizes S -adenosyl methionine SAMe as the methyl donor.

The major physiologic triggers of adrenaline release center upon stresses , such as physical threat, excitement, noise, bright lights, and high or low ambient temperature.

All of these stimuli are processed in the central nervous system. This is most often done in response to stress. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors , causing cell depolarization and an influx of calcium through voltage-gated calcium channels.

Calcium triggers the exocytosis of chromaffin granules and, thus, the release of adrenaline and noradrenaline into the bloodstream.

VMAT1 is also responsible for transporting newly synthesized adrenaline from the cytosol back into chromaffin granules in preparation for release.

Unlike many other hormones adrenaline as with other catecholamines does not exert negative feedback to down-regulate its own synthesis. Its action is terminated with reuptake into nerve terminal endings, some minute dilution, and metabolism by monoamine oxidase [82] and catechol- O -methyl transferase.

Extracts of the adrenal gland were first obtained by Polish physiologist Napoleon Cybulski in These extracts, which he called nadnerczyna "adrenalin" , contained adrenaline and other catecholamines.

Bates discovered adrenaline's usage for eye surgeries prior to 20 April The first hormone to be identified, it remains a crucial, firstline treatment for cardiac arrests, severe allergic reactions and other conditions.

An adrenaline junkie is somebody who engages in sensation-seeking behavior through "the pursuit of novel and intense experiences without regard for physical, social, legal or financial risk".

The term relates to the increase in circulating levels of adrenaline during physiological stress. Nevertheless, adrenaline infusion alone does increase alertness [91] and has roles in the brain including the augmentation of memory consolidation.

Adrenaline has been implicated in feats of great strength, often occurring in times of crisis. For example, there are stories of a parent lifting part of a car when their child is trapped underneath.

From Wikipedia, the free encyclopedia. Redirected from Epinephrine. Hormone and medication. This article is about the natural hormone. For the medication, see Epinephrine medication.

For other uses, see Adrenaline disambiguation. Ball-and-stick model of the zwitterionic form of adrenaline found in the crystal structure [1].

A01AD01 WHO B02BC09 WHO C01CA24 WHO R01AA14 WHO R03AA01 WHO S01EA01 WHO. IUPAC name. Interactive image.

CNC[C H] O c1ccc O c O c1. Main article: Epinephrine medication. See also: Adrenergic receptor. Play media.

Biosynthetic pathways for catecholamines and trace amines in the human brain [76] [77] [78]. L -Phenylalanine. L -Tyrosine. L -DOPA.

N -Methylphenethylamine. N -Methyltyramine. Main article: History of catecholamine research. See also: Novelty seeking.

Main article: Hysterical strength. Acta Chem. Veterinary Research Communications. Springer Science and Business Media LLC. Acta Pharmacologica et Toxicologica.

T; Weinkove, C. Annals of Clinical Biochemistry. SAGE Publications. The American Society of Health-System Pharmacists.

Retrieved 15 August Archived from the original on 8 September Marks' Basic Medical Biochemistry: A Clinical Approach 4th ed. In Sydor A, Brown RY eds.

Molecular Neuropharmacology: A Foundation for Clinical Neuroscience 2nd ed. New York, USA: McGraw-Hill Medical.

Epinephrine occurs in only a small number of central neurons, all located in the medulla. Epinephrine is involved in visceral functions, such as the control of respiration.

It is also produced by the adrenal medulla. Essentials of Medical Physiology. Elsevier India. Venomous Animals and Their Venoms: Venomous Vertebrates.

Cambridge University Press. Glucose Homeostasis and Insulin Resistance. Bentham Science Publishers. Pediatric Clinics of North America.

The Cochrane Database of Systematic Reviews 1 : CD Journal of Pharmaceutical and Biomedical Analysis. Annual Review of Pharmacology and Toxicology.

The New England Journal of Medicine. The Journal of Physiology. Acta Physiol Scand. Bibcode : Natur. British Journal of Diseases of the Chest.

Journal of Applied Physiology. Evidence that medulliadrenal secretion is not continuous". Am J Physiol. The American Journal of Physiology.

Acta Physiologica Scandinavica. Klinische Wochenschrift. Clinical Science.

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